Show simple item record
dc.contributor.author |
Myslíková, Kateřina
|
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dc.contributor.author |
Komersová, Alena
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dc.contributor.author |
Lochař, Václav
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dc.date.accessioned |
2020-05-14T10:22:20Z |
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dc.date.available |
2020-05-14T10:22:20Z |
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dc.date.issued |
2016 |
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dc.identifier.isbn |
978-80-7560-015-8 |
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dc.identifier.issn |
1211-5541 |
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dc.identifier.uri |
https://hdl.handle.net/10195/75391 |
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dc.description.abstract |
The aim of this paper is to present the use of a reaction and a dissolution kinetic
approach for evaluating the dissolution profile of a drug. As model substances,
two controlled-release formulations (with different type of matrix) with tramadol
hydrochloride were chosen. Release kinetics of tramadol hydrochloride was
studied at isothermal conditions (37 °C) and at different pH values for media used
for dissolution. The dissolution profiles obtained by using HPLC with UV
detection were fitted by the first-order kinetic model, Korsmeyer–Peppas, Higuchi,
and Weibull models. The main results of regression analysis were the
determination of the first-order release rate constant (k1), the release exponent (n)
from Korsmeyer–Peppas model, Higuchi constant (KH), and the parameters of
Weibull model (b, λ). |
en |
dc.format |
p. 67–79 |
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dc.language.iso |
en |
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dc.publisher |
University of Pardubice |
en |
dc.relation.ispartof |
Scientific papers of the University of Pardubice. Series A, Faculty of Chemical Technology. 22/2016 |
en |
dc.rights |
open access |
en |
dc.title |
Release kinetics of tramadol hydrochloride from solid drug formulations |
en |
dc.type |
Article |
en |
dc.peerreviewed |
yes |
en |
dc.publicationstatus |
published |
en |
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