Abstrakt:
The aim of this paper is to present the use of a reaction and a dissolution kinetic
approach for evaluating the dissolution profile of a drug. As model substances,
two controlled-release formulations (with different type of matrix) with tramadol
hydrochloride were chosen. Release kinetics of tramadol hydrochloride was
studied at isothermal conditions (37 °C) and at different pH values for media used
for dissolution. The dissolution profiles obtained by using HPLC with UV
detection were fitted by the first-order kinetic model, Korsmeyer–Peppas, Higuchi,
and Weibull models. The main results of regression analysis were the
determination of the first-order release rate constant (k1), the release exponent (n)
from Korsmeyer–Peppas model, Higuchi constant (KH), and the parameters of
Weibull model (b, λ).
