xmlui.ArtifactBrowser.SimpleSearch.filter.source:Scientific papers of the University of Pardubice. Series A, Faculty of Chemical Technology. 23/2017
ISSN:1211-5541
Abstract:
An automated method for the extended release tablet processing and
determination of tramadol hydrochloride in matrix tablets containing coprocessed
dry binders has been developed by using a bench-top robotic system
connected with HPLC system. The automated operations include (i) disintegration
steps of the dosage form, (ii) homogenisation, (iii) setting time, (iv) filtration, (v)
dilution, and (vi) injection of a sample into the HPLC vials or chromatographic
system. The method developed has been optimized and validated; recoveries of
spike tests being found in the range of 97.8-99.6 %. The relative standard
deviation representing the precision of the method was 1.02 % for tramadol hydrochloride in tablets with DisintequikTM MCC 25 and 1.15 % for tramadol
hydrochloride in tablets with Prosolv® SMCC 90. The validated method was
applied to the determination of the target substance in samples of two commercial
pharmaceutical formulations: Tralgit SR 100 and Tramadol Retard Actavis 100
mg.
