Zdrojový dokument:Scientific papers of the University of Pardubice. Series A, Faculty of Chemical Technology. 25/2019
ISSN:1211-5541
Abstrakt:
In this paper, the suitability of nanomaterials for drug delivery systems was studied,
including nanoparticle and nanofiber diameters measurement, when using the
hydrodynamic light scattering, scanning electron microscopy, the optimization of
protein concentration for adsorption, and of protein release assessment. The advantage
of nanomaterials is their large surface area. The aim of a series of sorption experiments
was to monitor the rate of sorption of ovalbumin (OVA) on three types of chitosan (CS)-
based nanomaterial carriers – the nanoparticles of chitosan, the nanoparticles of
chitosan-grafted-functionalized copolymer of polyacrylamide with polylactic acid
(CS/PLA/PAA), and the electrospun nanofibers. In the nanomaterials, the loading
efficacy and loading capacity were calculated and compared.