Comparison of loading efficacy and capacity of ovalbumin modified chitosan-based nanoparticles and nanofibers
ČlánekOtevřený přístuppeer-reviewedpublishedDatum publikování
2019
Vedoucí práce
Oponent
Název časopisu
Název svazku
Vydavatel
University of Pardubice
Abstrakt
In this paper, the suitability of nanomaterials for drug delivery systems was studied,
including nanoparticle and nanofiber diameters measurement, when using the
hydrodynamic light scattering, scanning electron microscopy, the optimization of
protein concentration for adsorption, and of protein release assessment. The advantage
of nanomaterials is their large surface area. The aim of a series of sorption experiments
was to monitor the rate of sorption of ovalbumin (OVA) on three types of chitosan (CS)-
based nanomaterial carriers – the nanoparticles of chitosan, the nanoparticles of
chitosan-grafted-functionalized copolymer of polyacrylamide with polylactic acid
(CS/PLA/PAA), and the electrospun nanofibers. In the nanomaterials, the loading
efficacy and loading capacity were calculated and compared.
Rozsah stran
p. 53 - 64
ISSN
1211-5541
Trvalý odkaz na tento záznam
Projekt
Zdrojový dokument
Scientific papers of the University of Pardubice. Series A, Faculty of Chemical Technology. 25/2019
Vydavatelská verze
Přístup k e-verzi
open access
Název akce
ISBN
978-80-7560-243-5
Studijní obor
Studijní program
Signatura tištěné verze
Umístění tištěné verze
Přístup k tištěné verzi
Klíčová slova
protein adsorption, protein release, loading efficacy, loading capacity, nanomaterials