Publikace: Effects of Charged Oxime Reactivators on the HK-2 Cell Line in Renal Toxicity Screening
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Autoři
Handl, Jiří
Malinak, David
Čapek, Jan
Andrys, Rudolf
Roušarová, Erika
Hauschke, Martina
Brůčková, Lenka
Česla, Petr
Roušar, Tomáš
Musilek, Kamil
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American Chemical Society
Abstrakt
Oxime cholinesterase reactivators (oximes) are used to counteract organophosphate intoxication. Charged oximes are administered via intramuscular or intravenous injection when the majority of dose is unmetabolized and is excreted as urine. In this study, the effects of selected double charged oximes were determined in the HK-2 cell line as a model for renal toxicity screening. Some effects on dehydrogenase activity were found for obidoxime, asoxime (syn. HI-6), K027, and K203. The effects of K868 and K869 were found to be unreliable due to rapid degradation of both chlorinated oximes in the assay medium, resulting for K868 in an isoxazole-pyridinium product.
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Klíčová slova
oxime cholinesterase reactivators, HK-2 Cells, renal toxicity, dehydrogenase activity, oximové reaktivátory cholinesterázy, HK-2 buňky, renální toxicita, dehydrogenázová aktivita