Modeling and prediction of the gradient retention data for ultrahigh performance liquid chromatography of benzodiazepines

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dc.contributor.author Valigurová, Petra
dc.contributor.author Váňová, Jana
dc.contributor.author Česla, Petr
dc.contributor.editor Adam, Martin
dc.date.accessioned 2021-09-22T12:12:41Z
dc.date.available 2021-09-22T12:12:41Z
dc.date.issued 2021
dc.identifier.isbn 978-80-7560-387-6
dc.identifier.issn 1211-5541
dc.identifier.uri https://hdl.handle.net/10195/78455
dc.description.abstract This paper presents a method for prediction of the gradient retention times of six samples of benzodiazepines – phenazepam, pyrazolam, flubromazepam, meclonazepam, diclazepam, and diazepam. Isocratic and gradient separation of the compounds of interest was achieved on a Luna Omega C18 column followed by RP-LC/MS detection. The results have shown good agreement between the predicted and experimental retention data; however, higher differences were obtained for fast gradients in the ultrahigh performance separation mode. en
dc.format p. 61-71
dc.language.iso en
dc.publisher University of Pardubice en
dc.relation.ispartof Scientific papers of the University of Pardubice. Series A, Faculty of Chemical Technology. 27/2021 en
dc.rights open access en
dc.subject benzodiazepines en
dc.subject liquid chromatography en
dc.subject gradient elution en
dc.subject prediction of retention en
dc.title Modeling and prediction of the gradient retention data for ultrahigh performance liquid chromatography of benzodiazepines en
dc.type Article en
dc.peerreviewed yes en
dc.publicationstatus published en


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