Digitální knihovnaUPCE
 

Inhibitory effect of carbamates in two types of cholinesterases

Článekpeer-reviewedpublished
Náhled

Datum publikování

2013

Vedoucí práce

Oponent

Název časopisu

Název svazku

Vydavatel

University of Pardubice

Abstrakt

Inhibitory effect of substituted 3-(diethylaminophenyl) phenyl carbamates in two types of cholineserases (acetylcholinesterase and butyrylcholinesterase) was determined. Inhibiting effectiveness was described by the value of IC50 (50 % inhibitory concentration). Modified spectrophotometric Ellman's method was used. Two types of choline esters were used as substrates for cholinesterases. It was proved that the carbamates chosen are quite effective inhibitors of cholinesterases. The most effective inhibitor of acetylcholinesterase is 3-(diethylaminophenyl) phenyl carbamate with the value of IC50 = 1.52 μM and the most effective inhibitor of butyrylcholinesterase is 3-(diethylaminophenyl) (3- nitrophenyl) carbamate with the value of IC50 = 1.70 μM.

Rozsah stran

p. 49–56

ISSN

1211-5541

Trvalý odkaz na tento záznam

Projekt

Zdrojový dokument

Scientific papers of the University of Pardubice. Series A, Faculty of Chemical Technology. 19/2013

Vydavatelská verze

Přístup k e-verzi

open access

Název akce

ISBN

978-80-7395-748-3

Studijní obor

Studijní program

Signatura tištěné verze

Umístění tištěné verze

Přístup k tištěné verzi

Klíčová slova

Endorsement

Review

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