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dc.contributor.author |
Laštovička, Petr
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dc.contributor.author |
Čermák, Tomáš
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dc.contributor.author |
Hájek, Filip
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dc.contributor.author |
Líbalová, Martina
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dc.contributor.author |
Nováková Mužáková, Vladimíra
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dc.contributor.author |
Skalický, Jiří
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dc.contributor.author |
Čegan, Alexander
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dc.date.accessioned |
2020-05-14T10:54:55Z |
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dc.date.available |
2020-05-14T10:54:55Z |
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dc.date.issued |
2016 |
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dc.identifier.isbn |
978-80-7560-015-8 |
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dc.identifier.issn |
1211-5541 |
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dc.identifier.uri |
https://hdl.handle.net/10195/75392 |
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dc.description.abstract |
Insulin resistance in type 2 diabetic patients reduces activation of PPAR, which
may lead to accumulation of branched-chain fatty acids, as well as saturated fatty
acids, when natural sources of these fatty acids are dairy products. The aim of our
study was to verify whether or not the accumulation of the branched chain fatty
acids takes place in type 2 diabetes and, if so, to specify the corresponding lipid
fraction. Totally 23 anonymised plasma samples of type 2 diabetic patients had
been collected and subsequently divided by glycosidic haemoglobin levels into two
groups of 11 compensated and 12 decompensated; the plasma of 10 healthy blood
donors being further processed. At first, the samples were divided into particular
lipid classes using thin layer chromatography. Then, we set the content of
individual fatty acids in all lipid classes using gas chromatography. The results were calculated and evaluated statistically by applying the SigmaStat 3.5
program. It has been found that the most abundant branched chain fatty acid is
14-methylhexadecanoic acid as statistically significant increase of this acid was
found in both compensated diabetics (p # 0.001) and decompensated ones (p #
0.001) in comparison with controls. The 14-methylhexadecanoic acid was
ascertained in the diacylglycerol fraction, as well as in free fatty acid fraction of
the compensated (p = 0.008) and decompensated (p = 0.007) diabetics.
Furthermore, an increase in the content of branched-chain fatty acids in
diabetic patients has been proved. An accumulation of these substances in
diabetics thus raises a question on their actual effect on the human organism. |
en |
dc.format |
p. 57–66 |
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dc.language.iso |
en |
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dc.publisher |
University of Pardubice |
en |
dc.relation.ispartof |
Scientific papers of the University of Pardubice. Series A, Faculty of Chemical Technology. 22/2016 |
en |
dc.rights |
open access |
en |
dc.title |
Determination of branched chain fatty acids in plasma of type 2 diabetics |
en |
dc.type |
Article |
en |
dc.peerreviewed |
yes |
en |
dc.publicationstatus |
published |
en |
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