Digitální knihovnaUPCE
 

The non-radioactive local lymph node assay: Skin sensitisation and irritation testing

ČlánekOtevřený přístuppeer-reviewedpublisher's version
Náhled

Datum publikování

2009

Vedoucí práce

Oponent

Název časopisu

Název svazku

Vydavatel

University of Pardubice

Abstrakt

This study was performed to investigate whether alternative endpoints of the local lymph node assay, non radioactive (LLNA-nR) like the ear weight and count cells would give additional information about the sensitizing/irritating potential of a tested substance. The legislation of REACH prefers alternative testing for skin sensitization and irritation. We have performed classic testing methods for skin irritation, for skin sensitization and alternative method LLNAnR with verified skin sensitizers, skin irritants and with some compounds, which were intended to be subjected to registration process according to REACH and other legislation rules. The aim of this paper was to test the hypothesis that it would be possible to use the LLNAnR testing method as single stand-alone method for the evaluation of sensitizing and irritation potential of untested chemicals. There is not only one test for simple determination of two skin toxicity endpoints, sensitization and skin irritation to date.

Rozsah stran

p. 63–72

ISSN

1211-5541

Trvalý odkaz na tento záznam

Projekt

Zdrojový dokument

Scientific papers of the University of Pardubice. Series A, Faculty of Chemical Technology. 15/2009

Vydavatelská verze

Přístup k e-verzi

open access

Název akce

ISBN

978-80-7395-239-6

Studijní obor

Studijní program

Signatura tištěné verze

Umístění tištěné verze

Přístup k tištěné verzi

Klíčová slova

Endorsement

Review

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