Anti-Parkinson drug biperiden inhibits enzyme acetylcholinesterase
ČlánekOtevřený přístuppeer-reviewedpublishedSoubory
Datum publikování
2017
Vedoucí práce
Oponent
Název časopisu
Název svazku
Vydavatel
Abstrakt
Biperiden is a drug used in Parkinson disease treatment. It acts as antagonist of muscarinic receptor activated by acetylcholine. Acetylcholinesterase is an enzyme inhibited by various compounds, however there has not been proposed evidence about interaction with biperiden molecule. Therefore, we investigated this interaction using standard Ellman´s assay and experimental data were completed with in-silico prediction by SwissDock docking software. We revealed inhibition mechanism and inhibition constant was calculated to be 1.11 mmol/l; interaction of biperiden occurs in peripheral anionic subsite. Biperiden appeared to be very weak inhibitor but it can serve as a leading structure in a pharmacological research.
Rozsah stran
p. 1-5
ISSN
2314-6133
Trvalý odkaz na tento záznam
Projekt
Zdrojový dokument
Biomed Research International, volume 2017, issue: 2017
Vydavatelská verze
https://www.hindawi.com/journals/bmri/2017/2532764/
Přístup k e-verzi
open access
Název akce
ISBN
Studijní obor
Studijní program
Signatura tištěné verze
Umístění tištěné verze
Přístup k tištěné verzi
Klíčová slova
Acetylcholinesterase, biperiden, inhibitor, docking, Acetylcholinesterasa, biperiden, inhibitor, docking