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Cytotoxicity of Naturally Occurring Isoquinoline Alkaloids of Different Structural Types

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Abstrakt

Forty-six isoquinoline alkaloids, of eleven structural types isolated in our laboratory, have been evaluated for their cytotoxicity against two cancer cell lines (Caco-2 and Hep-G2 cancer cells), as well as against normal human lung fibroblast cells. Only scoulerine, aromoline, berbamine and parfumidine showed significant cytotoxic effects, but only scoulerine was active against both Caco-2 and Hep-G2 cells (IC50 values 6.44 +/- 0.87 and 4.57 +/- 0.42, respectively). Unfortunately, except for parfumidine, the other active alkaloids were also cytotoxic to the normal human lung fibroblast cells.

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p. 753-756

ISSN

1934-578X

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Natural Product Communications, volume 11, issue: 6

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Isoquinoline alkaloids, Scoulerine, Cytotoxicity, Caco-2, Hep-G2, MRC-5, Isochinolinové alkaloidy, Skoulerin, Cytotoxicita, Caco-2, Hep-G2, MRC-5

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