Abstract:
A conductometric method is proposed to determine the sparingly soluble
ion-associate of Distigmine. A comparison between conductometric and ISEs values
has shown that the conductometric method is suitable, rapid, and easy-to-perform.
The Distigmine-ISE is successfully used for the determination of solubility products
of different sparingly soluble salts of Distigmine of the Ds3PM2, Ds3PT2, Ds2SM,
Ds2ST, DsTPB2, DsRein2 and DsPi2 stoichiometry. The solubility products
determined by Ds-ISE were found to be in good agreement with the values obtained
by conductometric method. Finally, the solubility products for Ds3PM2, Ds3PT2,
Ds2SM, Ds2ST, DsTPB2, DsRein2, and DsPi2 were found to be 4.92×10-25, 5.61×10-25,
2.27×10-28, 4.71×10-28, 3.11×10-14, 5.91×10-15, and 6.40×10-14, respectively.
