Comparison of loading efficacy and capacity of ovalbumin modified chitosan-based nanoparticles and nanofibers

Abstract

In this paper, the suitability of nanomaterials for drug delivery systems was studied, including nanoparticle and nanofiber diameters measurement, when using the hydrodynamic light scattering, scanning electron microscopy, the optimization of protein concentration for adsorption, and of protein release assessment. The advantage of nanomaterials is their large surface area. The aim of a series of sorption experiments was to monitor the rate of sorption of ovalbumin (OVA) on three types of chitosan (CS)- based nanomaterial carriers – the nanoparticles of chitosan, the nanoparticles of chitosan-grafted-functionalized copolymer of polyacrylamide with polylactic acid (CS/PLA/PAA), and the electrospun nanofibers. In the nanomaterials, the loading efficacy and loading capacity were calculated and compared.