Publikace: New targeting system for antimycotic drugs: beta-Glucosidase sensitive Amphotericin B-star poly(ethylene glycol) conjugate
Článekopen accesspeer-reviewedpostprint| dc.contributor.author | Drabina, Pavel | |
| dc.contributor.author | Sedlák, Miloš | |
| dc.contributor.author | Bílková, Eliška | |
| dc.contributor.author | Šimůnek, Petr | |
| dc.contributor.author | Buchta, Vladimír | |
| dc.date.accessioned | 2010-10-01T12:14:07Z | |
| dc.date.available | 2010-10-01T12:14:07Z | |
| dc.date.issued | 2008 | |
| dc.description.abstract | A new targeting potentially intravenous conjugate Amphotericin B (AMB)-star poly(ethylene glycol) (sPEG) (M = 25,160) has been synthesized and characterized. It contains a beta-D-glucopyranoside molecular switch which is sensitive to beta-glucosidases (E. C. 3.2.1.21). The beta-glucosidase-catalyzed release of AMB from the polymeric carrier was proved in vitro by means of spectrophotometry and HPLC. (C) 2008 Elsevier Ltd. All rights reserved. | cze |
| dc.format | p. 2952-2956 | eng |
| dc.identifier.doi | 10.1016/j.bmcl.2008.03.065 | |
| dc.identifier.issn | 0960-894X | |
| dc.identifier.uri | https://hdl.handle.net/10195/37279 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | eng |
| dc.publicationstatus | postprint | eng |
| dc.publisher | Elsevier | cze |
| dc.relation.ispartof | Bioorganic and Medicinal Chemistry Letters. 2008, vol. 18, issue 9 | eng |
| dc.relation.publisherversion | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF9-4S50K3Y-1&_user=640852&_coverDate=05%2F01%2F2008&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000032310&_version=1&_urlVersion=0&_userid=640852&md5=5589e509fb97346fc3fd02e8e7a893e2&searchtype=a | |
| dc.rights | open access | eng |
| dc.title | New targeting system for antimycotic drugs: beta-Glucosidase sensitive Amphotericin B-star poly(ethylene glycol) conjugate | eng |
| dc.type | Article | eng |
| dspace.entity.type | Publication |
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