dc.contributor.author |
Agostinho Monteiro, Sara Eunice
|
|
dc.date.accessioned |
2020-04-08T10:09:39Z |
|
dc.date.available |
2020-04-08T10:09:39Z |
|
dc.date.issued |
2020 |
|
dc.date.submitted |
2019-12-05 |
|
dc.identifier |
Univerzitní knihovna (archiv). Práce není přístupná. |
cze |
dc.identifier.uri |
https://hdl.handle.net/10195/75301 |
|
dc.description.abstract |
Prostaglandins are a group of lipid mediators with multiple
pharmaceutical and veterinary applications.
This thesis describes the efforts made in the development of a new
strategy for the synthesis of Alfaprostol ů-chain. More specifically,
several attempts were made in the preparation of the propargyl alcohol
connection present in this molecule.
Literature described two main methodologies for preparation of
optically active propargylic alcohols, namely: asymmetric reduction of
a propargylic ketone or the asymmetric alkynylation of a carbonyl
group. Both mentioned methodologies were studied and applied to
target molecule.
Stille coupling has been successfully used to afford propargylic ketone
susceptible of asymmetric reduction.
The direct preparation of propargylic alcohol with adequate
stereoselectivity using Corey lactone derivatives and 3-
cyclohexylpropanal as starting materials was also deeply studied.
Furthermore, it has also been used in the stereoselective studies made
afterwards. |
eng |
dc.format |
166 s. |
|
dc.language.iso |
eng |
|
dc.publisher |
Univerzita Pardubice |
cze |
dc.rights |
Práce není přístupná. |
cze |
dc.subject |
alfaprostol |
eng |
dc.subject |
alkynylation |
eng |
dc.subject |
propargyl alcohol |
eng |
dc.subject |
propargyl ketone |
eng |
dc.subject |
prostaglandins |
eng |
dc.subject |
stille coupling |
eng |
dc.title |
Příprava pokročilých prostaglandinových meziproduktů |
cze |
dc.title.alternative |
Synthesis of advanced prostaglandin intermediates |
eng |
dc.type |
disertační práce |
cze |
dc.contributor.referee |
Doležal, Martin |
|
dc.contributor.referee |
Weidlich, Tomáš |
|
dc.date.accepted |
2020-03-02 |
|
dc.description.department |
Fakulta chemicko-technologická |
cze |
dc.thesis.degree-discipline |
Organic Technology |
cze |
dc.thesis.degree-name |
Ph.D. |
|
dc.thesis.degree-grantor |
Univerzita Pardubice. Fakulta chemicko-technologická |
cze |
dc.identifier.signature |
D40280 |
|
dc.thesis.degree-program |
Chemistry and Chemical Technology |
cze |
dc.identifier.stag |
39601 |
|
dc.description.grade |
Dokončená práce s úspěšnou obhajobou |
cze |