dc.contributor.author |
Machálková, Aneta
|
cze |
dc.contributor.author |
Melounková, Lucie
|
cze |
dc.contributor.author |
Vinklárek, Jaromír
|
cze |
dc.contributor.author |
Císařová, Ivana
|
cze |
dc.contributor.author |
Honzíček, Jan
|
cze |
dc.date.accessioned |
2020-03-19T12:55:50Z |
|
dc.date.available |
2020-03-19T12:55:50Z |
|
dc.date.issued |
2019 |
eng |
dc.identifier.issn |
0020-1693 |
eng |
dc.identifier.uri |
https://hdl.handle.net/10195/74950 |
|
dc.description.abstract |
This study describes synthesis of water-soluble vanadocene and 1,1'-dimethylvanadocene compounds bearing dithiocarbamate ligands. All prepared compounds were characterized by analytical and spectroscopic methods. The structure of [(eta(5)-C5H4Me)(2)V{S2CN(CH2)(4)O}]Cl was determined by single-crystal X-ray diffraction analysis. The cytotoxicity of the synthesized compounds was investigated on human leukemia cells MOLT-4. The derivatives bearing cyclic dithiocarbamates show considerably stronger activity than reported for cisplatin. |
eng |
dc.format |
p. 125-130 |
eng |
dc.language.iso |
eng |
eng |
dc.publisher |
Elsevier Science SA |
eng |
dc.relation.ispartof |
Inorganica Chimica Acta, volume 485, issue: January |
eng |
dc.rights |
open access (CC BY-NC-ND 4.0) |
eng |
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
dc.subject |
Metallocene |
eng |
dc.subject |
Vanadium |
eng |
dc.subject |
S,S-Chelating ligands |
eng |
dc.subject |
EPR spectroscopy |
eng |
dc.subject |
Cytotoxicity |
eng |
dc.subject |
Metallocen |
cze |
dc.subject |
vanad |
cze |
dc.subject |
EPR spektroskopie |
cze |
dc.subject |
cytotoxicita |
cze |
dc.title |
Synthesis, characterization and cytotoxic activity of vanadocene dithiocarbamate complexes |
eng |
dc.title.alternative |
Příprava charakterizace a cytotoxicita dithiokarbamátových vanadocenovch komplexů |
cze |
dc.type |
article |
eng |
dc.description.abstract-translated |
Tato studie popisuje přípravu ve vodě rozpustných komplexů vanadocenu a dimethylvanadocenu s dithiokarbamátovými ligandy. Tyto komplexy byly charakterizovány analytickými a spektroskopickými metodami. Jejich cytotoxicita byla studována na leukemických buňkách MOLT-4. |
cze |
dc.peerreviewed |
yes |
eng |
dc.publicationstatus |
postprint |
eng |
dc.identifier.doi |
10.1016/j.ica.2018.10.010 |
eng |
dc.relation.publisherversion |
https://www.sciencedirect.com/science/article/pii/S0020169318311745 |
eng |
dc.identifier.wos |
000448409900017 |
eng |
dc.identifier.obd |
39883235 |
eng |