Show simple item record
dc.contributor.author |
Mrózek, Ondřej
|
cze |
dc.contributor.author |
Šebestová, Lucie
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cze |
dc.contributor.author |
Vinklárek, Jaromír
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cze |
dc.contributor.author |
Řezáčová, Martina
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cze |
dc.contributor.author |
Eisner, Aleš
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cze |
dc.contributor.author |
Růžičková, Zdeňka
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cze |
dc.contributor.author |
Honzíček, Jan
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cze |
dc.date.accessioned |
2017-05-11T11:11:09Z |
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dc.date.available |
2017-05-11T11:11:09Z |
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dc.date.issued |
2016 |
eng |
dc.identifier.issn |
1434-1948 |
eng |
dc.identifier.uri |
http://hdl.handle.net/10195/67600 |
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dc.description.abstract |
A series of the cyclopentadienyl and indenyl molybdenum compounds bearing alkylammonium functions [(eta(5)-Cp')Mo(CO)(2)(L-N,L-N)][BF4](2) were synthesized and characterized by analytical and spectroscopic methods. The structures of [{eta(5)-C5H4CH2CH2NH(CH2)(5)}Mo(CO)(2)(4,7-Ph-2-phen)][BF4](2) (4,7-Ph-2-phen = 4,7-dipheny1-1,10-phenanthroline) and [(eta(5)-C9H6CH2CH2NHMe2)Mo(CO)(2)(phen)][BF4](2) (phen = 1,10-phenanthroline) were determined by X-ray crystallography. All of the synthesized compounds exhibit high activity against the human leukemia cell lines MOLT-4 and HL-60. They are approximately one order of magnitude more active than cisplatin. This study has proven that the modification of the outer coordination sphere of molybdenum complexes has a strong impact on their activity and may be successfully used for the design of new highly cytotoxic active species. |
eng |
dc.format |
p. 519-529 |
eng |
dc.language.iso |
eng |
eng |
dc.relation.ispartof |
European Journal of Inorganic Chemistry, volume 2016, issue: 4 |
eng |
dc.rights |
open access |
eng |
dc.subject |
molybdenum |
eng |
dc.subject |
indenyl |
eng |
dc.subject |
cytotoxicity |
eng |
dc.subject |
molybden |
cze |
dc.subject |
indenyl |
cze |
dc.subject |
cytotoxicita |
cze |
dc.title |
Highly Water-Soluble Cyclopentadienyl and Indenyl Molybdenum(II) Complexes - Second Generation of Molybdenum-Based Cytotoxic Agents |
eng |
dc.title.alternative |
Cyklopentadienylové a indenylové komplexy molybdenu rozpustné ve vodě - druhá generace cytotoxických sloučenin molybdenu |
cze |
dc.type |
article |
eng |
dc.description.abstract-translated |
Práce popisuje přípravu cyklopentadienylových a indenylových komplexů molybdenu s alkylammoniovými funkčními skupinami a jejich charakterizaci analytickými a spektroskopickými metodami. Struktury komplexů [{eta(5)-C5H4CH2CH2NH(CH2)(5)}Mo(CO)(2)(4,7-Ph-2-phen)][BF4](2) (4,7-Ph-2-phen = 4,7-dipheny1-1,10-phenanthroline) a [(eta(5)-C9H6CH2CH2NHMe2)Mo(CO)(2)(phen)][BF4](2) (phen = 1,10-phenanthroline) byly urřený RTG strukturní analýzou. Připravené komplexy vykazují aktivitu vůči leukemizkým buněčným liniím MOLT-4 a HL-60. Jsou přibližně o jeden řád účinnější než cisplatina. |
cze |
dc.peerreviewed |
yes |
eng |
dc.publicationstatus |
postprint |
eng |
dc.identifier.doi |
10.1002/ejic.201501133 |
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dc.identifier.wos |
000370352400009 |
|
dc.identifier.scopus |
2-s2.0-84957439061 |
|
dc.identifier.obd |
39877384 |
eng |
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