Digitální knihovnaUPCE
 

New type of PVC-membrane Ion-selective electrodes and their applicability to determine some antidepressand drugs

Článekpeer-reviewedpublished
Náhled

Datum publikování

2010

Vedoucí práce

Oponent

Název časopisu

Název svazku

Vydavatel

Univerzita Pardubice

Abstrakt

The construction and electrochemical characterisation of potentiometric sensors of the PVC-membrane type are described being developed for the determination of selected antidepressants; namely: Olanzapine, Oxazepam, and Lorazepam. The sensing PVC-membranes incorporate the ion-associates of the drug cations with ammonium reineckate as selective materials dispersed in 2-nitrophenyl-octylether (NPOE) or dibutyl sebacate (DBS) as the plasticizers of choice. These ISEs exhibit rapid, stable and nearly Nernstian response over a relatively wide concentration range of 1×10–7 mol l–1-0.01 mol l–1 for Olanzapine and 1×10–6-0.01 mol l–1 for Oxazepam and Lorazepam, in mild acidic solutions with pH 4.5. No interferences caused by either inorganic or organic species were found. The three electrodes developed have been tested for potentiometric titrations of all three drugs, as well as for their direct determination via the respective calibration curves. The individual experiments then resulted in average recovery rates in an interval of 34 Wassel A.A., Abdullatif S./Sci. Pap. Univ. Pardubice Ser. A 16 (2010) 33–55 98.4-99.2 %, with the R.S.D. of ca. ±1.5 % (n = 3) for all three analytes of interest. Finally, the method proposed has been applied to the determination of the three drugs in pharmaceutical formulations and urine, when the results obtained were comparable to those obtained with the reference HPLC measurements.

Rozsah stran

p. 33-55

ISSN

1211-5541

Trvalý odkaz na tento záznam

Projekt

Zdrojový dokument

Scientific papers of the University of Pardubice. Series A, Faculty of Chemical Technology. 16 (2010)

Vydavatelská verze

Přístup k e-verzi

Název akce

ISBN

978-80-7395-386-7 (Online)
978-80-7395-368-3 (Print)

Studijní obor

Studijní program

Signatura tištěné verze

47333-16

Umístění tištěné verze

Univerzitní knihovna (studovna)

Přístup k tištěné verzi

Klíčová slova

PVC-membrane, potentiometric titrations, HPLC measurements

Endorsement

Review

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