New type of PVC-membrane Ion-selective electrodes and their applicability to determine some antidepressand drugs
Článekpeer-reviewedpublishedDatum publikování
2010
Vedoucí práce
Oponent
Název časopisu
Název svazku
Vydavatel
Univerzita Pardubice
Abstrakt
The construction and electrochemical characterisation of potentiometric sensors of the PVC-membrane type are described being developed for the determination of selected antidepressants; namely: Olanzapine, Oxazepam, and Lorazepam. The sensing PVC-membranes incorporate the ion-associates of the drug cations with ammonium reineckate as selective materials dispersed in 2-nitrophenyl-octylether
(NPOE) or dibutyl sebacate (DBS) as the plasticizers of choice. These ISEs exhibit
rapid, stable and nearly Nernstian response over a relatively wide concentration range of 1×10–7 mol l–1-0.01 mol l–1 for Olanzapine and 1×10–6-0.01 mol l–1 for Oxazepam and Lorazepam, in mild acidic solutions with pH 4.5. No interferences caused by either inorganic or organic species were found. The three electrodes
developed have been tested for potentiometric titrations of all three drugs, as well
as for their direct determination via the respective calibration curves. The
individual experiments then resulted in average recovery rates in an interval of
34 Wassel A.A., Abdullatif S./Sci. Pap. Univ. Pardubice Ser. A 16 (2010) 33–55
98.4-99.2 %, with the R.S.D. of ca. ±1.5 % (n = 3) for all three analytes of interest.
Finally, the method proposed has been applied to the determination of the three
drugs in pharmaceutical formulations and urine, when the results obtained were comparable to those obtained with the reference HPLC measurements.
Rozsah stran
p. 33-55
ISSN
1211-5541
Trvalý odkaz na tento záznam
Projekt
Zdrojový dokument
Scientific papers of the University of Pardubice. Series A, Faculty of Chemical Technology. 16 (2010)
Vydavatelská verze
Přístup k e-verzi
Název akce
ISBN
978-80-7395-386-7 (Online)
978-80-7395-368-3 (Print)
978-80-7395-368-3 (Print)
Studijní obor
Studijní program
Signatura tištěné verze
47333-16
Umístění tištěné verze
Univerzitní knihovna (studovna)
Přístup k tištěné verzi
Klíčová slova
PVC-membrane, potentiometric titrations, HPLC measurements