Cyclodextrin-based potentiometric sensors for Metformin

Show simple item record Khaled, Elmorsy Kamel, Manal S. 2012-03-07T08:27:38Z 2012-03-07T08:27:38Z 2011
dc.identifier.isbn 978-80-7395-434-5 (printed)
dc.identifier.isbn 978-80-7395-435-2 (on-line)
dc.description.abstract -Cyclodextrins ( -CDs) based polyvinylchloride (PVC) electrodes were fabricated and applied for potentiometric determination of Metformin (Mf). Matrix composition optimization was done referring the effect of type and content of -CDs, anionic sites and plasticizer. Electrodes incorporated with 2-hydroxypropyl- -CD as sensing ionophore, sodium tetrakis (4-florophenyl) borate (NaTFPB) as anionic site and o-nitrophenyloctyl ether (o-NPOE) as electrode plasticizer showed the best electroanalytical performances. The fabricated electrodes worked satisfactorily in the concentration range from 10-6 to 10-2 mol L-1 with detection limit reaching 7×10-6 mol L-1 and fast response time of 8 s. The developed sensors possessed improved selectivity and have been successfully applied for the potentiometric determination of Mf in pharmaceutical formulation. Comparison of the obtained results with those provided by reference method revealed adequate accuracy for control assay. cze
dc.format p. 323-336
dc.language.iso eng
dc.publisher Univerzita Pardubice cze
dc.relation.ispartof Sensing in electroanalysis. K. Kalcher, R. Metelka, I. Švancara, K. Vytřas (Eds.).2011, Volume 6.
dc.rights open access
dc.subject potentiometric sensors cze
dc.subject cyclodextrins cze
dc.subject Metformin cze
dc.subject pharmaceutical analysis cze
dc.title Cyclodextrin-based potentiometric sensors for Metformin cze
dc.type Article cze
dc.peerreviewed yes
dc.publicationstatus published

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