Differential pulse anodic voltammetric determination of dapsone in pharmaceutical preparation using carbon paste and glassy carbon electrodes: application to quality control
ČlánekOtevřený přístuppeer-reviewedpublishedDatum publikování
2011
Vedoucí práce
Oponent
Název časopisu
Název svazku
Vydavatel
Univerzita Pardubice
Abstrakt
The voltammetric behavior of Dapsone has been carried out at carbon paste electrode
(CPE) and glassy carbon electrode (GCE) using cyclic voltammetry and differential pulse voltammetry. Dapsone undergoes a well-defined irreversible oxidation peak at both electrodes. The proposed methods were successfully utilized for the determination of Dapsone in various dosage forms without interference from matrix with acceptable precision (RSD < 1.46 %) and accuracy (RE < 1.2 %). Forced stability studies of drug in acid, basic and oxidative media were
monitored. Moreover, the CPE was used to study the in vitro release of Dapsone tablet, and testing tablet uniformity. The kinetic studies reveals first order with diffusion controlled release. The results compare favorably with data obtained by the official volumetric method.
Rozsah stran
p. 307-322
ISSN
Trvalý odkaz na tento záznam
Projekt
Zdrojový dokument
Sensing in electroanalysis. K. Kalcher, R. Metelka, I. Švancara, K. Vytřas (Eds.).2011, Volume 6.
Vydavatelská verze
Přístup k e-verzi
open access
Název akce
ISBN
978-80-7395-434-5 (printed)
978-80-7395-435-2 (on-line)
978-80-7395-435-2 (on-line)
Studijní obor
Studijní program
Signatura tištěné verze
Umístění tištěné verze
Přístup k tištěné verzi
Klíčová slova
dapsone, cyclic voltammetry, differential pulse voltammetry, stability studies, in-vitro release