Electrochemical determination of anaesthetic drug benoxinate hydrochloride
Článekpeer-reviewedpublishedDatum publikování
2010
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Univerzita Pardubice
Abstrakt
The electrochemical oxidation of Benoxinate hydrochloride (Ben) has been
studied in Britton-Robinson buffer at electrochemically pretreated glassy carbon
electrode (EA-GCE). Ben exhibits a well-defined irreversible oxidation peak over the
entire range of pH 2-11. Differential pulse voltammetry (DPV) was used to determine
the compound of interest in pure form, when the peak current varied linearly over the
range of 4.0 × 10-7 – 3.2 × 10-6 mol L-1; the limits of detection and quantification
being 8.3 × 10-8 mol L-1 and 2.8 × 10-7 mol L-1, respectively. The recovery was found
in the range of 99.3-100.7%, the relative standard deviation in the range of ±0.75-
1.25%. The respective method proposed could be applied to determine Ben in
pharmaceutical form.
Rozsah stran
p. 209-219
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Zdrojový dokument
Sensing in electroanalysis. K. Vytřas, K. Kalcher, I. Švancara (Eds.). 2010, Volume 5.
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open access
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978-80-7395-348-5 (printed)
978-80-7395-349-2 (on-line)
978-80-7395-349-2 (on-line)
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Klíčová slova
benoxinate hydrochloride, oxidation, glassy carbon electrode, bifferential pulse voltammetry, determination, pharmaceutical form