Sensors membrane electrodes for sensitive determination of hyoscine butylbromide in pharmaceutical formulation and in human plasma

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dc.contributor.author Wassel, Anwar A.
dc.contributor.author Abu-Talib, N. F.
dc.date.accessioned 2011-02-10T09:36:43Z
dc.date.available 2011-02-10T09:36:43Z
dc.date.issued 2010
dc.identifier.isbn 978-80-7395-348-5 (printed)
dc.identifier.isbn 978-80-7395-349-2 (on-line)
dc.identifier.uri http://hdl.handle.net/10195/38237
dc.description.abstract The proposed sensors of the construction of Hyoscine Butylbromide (HyB) ionselective electrodes based on the complex ion associate of hyoscine with tetraphenyl borate ionophor in the polyvinyl chloride (PVC) matrix with dioctyl phtalate and dibutyl sebathate as plasticizers. The electrochemical performance characteristics of the two HyB-selective electrodes were evaluated according to IUPAC standards. Sensors show stable potential response with near Nernstian slope of 52.42, 54.57 mV per decade for sensors denoted as № 1 and 2, respectively. Selectivity coefficients data for different organic and inorganic ions are also presented. The two sensors have fast response time (20-30s) and applicable over a wide range of the operational pH (6-10). The results obtained from the determination of HyB with the two proposed electrodes have shown the average recoveries of 98.6%, 99.6% for analysis of tablets and 100.17%, 99.01 for (spiked) human plasma. The data agree well with those obtained by the standard reference methods. eng
dc.format p. 229-242 eng
dc.language.iso eng
dc.publisher Univerzita Pardubice cze
dc.relation.ispartof Sensing in electroanalysis. K. Vytřas, K. Kalcher, I. Švancara (Eds.). 2010, Volume 5. eng
dc.rights open access eng
dc.subject direct potentiometry eng
dc.subject PVC sensors eng
dc.subject Hyoscine Butylbromide (HyB) eng
dc.subject ion-associate with tetraphenyl borate eng
dc.subject determination eng
dc.subject human plasma eng
dc.title Sensors membrane electrodes for sensitive determination of hyoscine butylbromide in pharmaceutical formulation and in human plasma eng
dc.type Article cze
dc.peerreviewed yes eng
dc.publicationstatus published eng


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