Chemometric analysis of biochemical laboratory data of oncology patients after morphine treatment
ČlánekOtevřený přístuppeer-reviewedpublishedDatum publikování
2006
Vedoucí práce
Oponent
Název časopisu
Název svazku
Vydavatel
Univerzita Pardubice
Abstrakt
Relationships among serum levels of morphine (M), morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) as well as the results of several standard biochemical tests were investigated in oncology patients, to whom morphine was administered. The level of the serum concentrations of M, M3G and M6G, determined by a new HPLC method, plays an important role in pain resistance: particularly the M3G/M6G ratio is extraordinarily important. The magnitude of this ratio is a complex function of the patient's gender, type of the morphine drug and tumor location. Studies of relations between the standard biochemical tests and the M, M3G, and M6G concentrations, and the M3G/M6G ratio, revealed a strong connection between M3G/M6G and the clearance of creatinine.
Rozsah stran
p. 315-330
ISSN
1211-5541
Trvalý odkaz na tento záznam
Projekt
Zdrojový dokument
Scientific papers of the University of Pardubice. Series A, Faculty of Chemical technology. 11(2005)
Vydavatelská verze
Přístup k e-verzi
open access
Název akce
ISBN
Studijní obor
Studijní program
Signatura tištěné verze
47333
Umístění tištěné verze
Univerzitní knihovna (studovna)
Přístup k tištěné verzi
Klíčová slova
chemometrie, biochemické testy, onkologie, pacienti, morfium