Digitální knihovnaUPCE
 

Chemometric analysis of biochemical laboratory data of oncology patients after morphine treatment

Článekpeer-reviewedpublished
Náhled

Datum publikování

2006

Vedoucí práce

Oponent

Název časopisu

Název svazku

Vydavatel

Univerzita Pardubice

Abstrakt

Relationships among serum levels of morphine (M), morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) as well as the results of several standard biochemical tests were investigated in oncology patients, to whom morphine was administered. The level of the serum concentrations of M, M3G and M6G, determined by a new HPLC method, plays an important role in pain resistance: particularly the M3G/M6G ratio is extraordinarily important. The magnitude of this ratio is a complex function of the patient's gender, type of the morphine drug and tumor location. Studies of relations between the standard biochemical tests and the M, M3G, and M6G concentrations, and the M3G/M6G ratio, revealed a strong connection between M3G/M6G and the clearance of creatinine.

Rozsah stran

p. 315-330

ISSN

1211-5541

Trvalý odkaz na tento záznam

Projekt

Zdrojový dokument

Scientific papers of the University of Pardubice. Series A, Faculty of Chemical technology. 11(2005)

Vydavatelská verze

Přístup k e-verzi

open access

Název akce

ISBN

Studijní obor

Studijní program

Signatura tištěné verze

47333

Umístění tištěné verze

Univerzitní knihovna (studovna)

Přístup k tištěné verzi

Klíčová slova

chemometrie, biochemické testy, onkologie, pacienti, morfium

Endorsement

Review

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