Příprava a disoluční kinetika matricových tablet s prodlouženým uvolňováním pentoxifylinu

Abstract

The subject of this bachelor thesis is the study of the kinetics of the release of the active pharmaceutical ingredient pentoxifylline from hydrophilic matrix tablets. In the theoretical part is discussed controlled release, dissolution process and suitable pharmacokinetic models. The experimental part focuses on the dissolution of hydrophilic matrix tablets in a dissolving medium of pH 1.2 and subsequent evaluation of obtained dissolution profiles using appropriate mathematical models. The result of this part is to determine the release rate constants of pentoxifylline from various dosage formulations and assessment of the effect of excipients (especially retardant components) on the dissolution profile of the drug.