Využití alfa-aminokyselin v syntéze dusíkatých heterocyklů

Mohite, Pravinkumar Hansraj

Publikace:
Využití alfa-aminokyselin v syntéze dusíkatých heterocyklů

Disertační práceopen access

dc.contributor.author	Mohite, Pravinkumar Hansraj
dc.contributor.referee	Cibulka, Radek
dc.contributor.referee	Romański, Jarosław
dc.date.accepted	2016-12-15
dc.date.accessioned	2017-01-23T10:58:58Z
dc.date.available	2017-01-23T10:58:58Z
dc.date.issued	2016
dc.date.submitted	2016-11-16
dc.description.abstract	Práce se zaměřuje na zavedení zbytku alfa-aminokyseliny do struktury pětičlenných dusíkatých heterocyklických sloučenin. Rešeršní část se zaměřila především na deriváty benzo[d]imidazolu a benzo[d]oxazolu. V experimentální části bylo navrženo a připraveno několik nových derivátů benzo[d]imidazolu nesoucích zbytek alfa-aminokyseliny připojený v poloze C2. Tyto opticky čisté primární aminy byly dále využity jako organokatalyzátory v asymetrických aldolových reakcích.	cze
dc.description.abstract-translated	This doctoral work focuses on introduction of alpha-amino acid pendants on five membered nitrogen heterocyclic compounds. The literature search has mainly been focused on benzo[d]imidazole and benzo[d]oxazole derivatives. In the experimental part, several new benzo[d]imidazole derivatives bearing a-amino acid residues attached at the C2 position were designed and prepared. These optically pure primary amines were further applied as organocatalysts in asymmetric aldol reactions.	eng
dc.description.defence	ZÁPIS O OBHAJOBĚ DISERTAČNÍ PRÁCE (Record concerning Ph.D. Thesis Defense) Competitor: MSc. Pravinkumar H. Mohite Ph.D. Thesis title: "Utilization of alpha-aminoacids in the synthesis of nitrogen heterocycles" Presence: see the enclosed Attendance Sheet Thesis defense was opened by the Chairman of the Committee - doc. Ing. Jiří Hanusek, Ph.D. - who stated that from seven designated Committee members including two opponents is five present thus allowing accomplishment of the thesis examination. Further he excused prof. Dr. Jarosław Romański and prof. RNDr. Petr Klán, Ph.D. Both of them cannot come to join the Committee due to their urgent duties. Thesis Supervisor - doc. Ing. Filip Bureš, Ph.D. - has also attended the defense. The Chairman briefly introduced competitor and announced that he fulfilled all the necessary requirements according to Study and Examination Rules of the Faculty of Chemical Technology, University of Pardubice. The Chairman also announced that the Competitor passed his Comprehensive Ph.D. Examination (State Doctoral Examination, September 29th 2015). Then thesis Supervisor apprised Committee with his positive formal opinions. Subsequently, the positive opinions of Head of Institute of Organic Chemistry and Technology, prof. Ing. Miloš Sedlák, DrSc., has been read by the Chairman of the Committee. Competitor Pravinkumar Mohite then gave a 20 minutes lecture about results obtained during his study. His lecture was appreciated by the Committee members. After that, opponents' expert opinions have been read; doc. Ing. Radek Cibulka read his opinions and then Chairman of the committee read the opinions of prof. Dr. Jarosław Romański. Opponents asked Competitor for appropriate answers. Competitor successfully answered all opponents' questions and suggestions. Then Ph.D. Thesis examination was opened for discussion: " prof. Ing. Dalimil Dvořák, CSc. - Conversion and yields of the performed reactions " doc. Ing. Roman Jambor, Ph.D. - Can be an aldol reaction catalysed by organometallic compounds? - Stability of the prepared compounds in solution " prof. RNDr. Milan Pour, Ph.D. - Possibility of a complexation of nitrogen heterocycles with the Cu atoms - Influence of the benzene ring substituents on the enantioselectivity " doc. Ing. Jiří Hanusek, Ph.D. - Possibility of racemization during N-methylation process Competitor successfully answered all Committee-members' questions and suggestions. Neither written or oral questions nor remarks were delivered to the Chairman of the Committee, therefore the public part of the Defense was closed. After that, all Committee members voted using printed forms (they are attached to this Record). On the basis of the voting the Chairman has announced that the result is: "passed" (vyhověl) At the end of session the chairman apprised Competitor with the result of voting and then announced that he will suggest to Dean of Faculty of Chemical Technology, prof. Ing. Petr Kalenda, CSc., the Ph.D. graduation of Pravinkumar Mohite. In Pardubice, December 15th 2016 Chairman of the Committee: doc. Ing. Jiří Hanusek, Ph.D. prof. Ing. Dalimil Dvořák, CSc. prof. RNDr. Milan Pour, Ph.D. doc. Ing. Roman Jambor, Ph.D. Opponent: doc. Ing. Radek Cibulka, Ph.D. Secretary of the Committee: Ing. Břetislav Brož	cze
dc.description.department	Fakulta chemicko-technologická	cze
dc.description.grade	Dokončená práce s úspěšnou obhajobou	cze
dc.format	115 s. + teze	cze
dc.identifier	Univerzitní knihovna (studovna)	cze
dc.identifier.signature	D35464
dc.identifier.stag	32322
dc.identifier.uri	https://hdl.handle.net/10195/66909
dc.language.iso	eng
dc.publisher	Univerzita Pardubice	cze
dc.rights	Bez omezení
dc.subject	benzo[d]imidazol	cze
dc.subject	alfa-aminokyselina	cze
dc.subject	amin	cze
dc.subject	aldolová reakce	cze
dc.subject	organokatalýza	cze
dc.subject	benzo[d]imidazole	eng
dc.subject	alpha-amino acid	eng
dc.subject	amine	eng
dc.subject	aldol reaction	eng
dc.subject	organocatalysis	eng
dc.thesis.degree-discipline	Organic Chemistry	cze
dc.thesis.degree-grantor	Univerzita Pardubice. Fakulta chemicko-technologická	cze
dc.thesis.degree-name	Ph.D.
dc.thesis.degree-program	Organic Chemistry	cze
dc.title	Využití alfa-aminokyselin v syntéze dusíkatých heterocyklů	cze
dc.title.alternative	Utilization of alpha-amino acids in the synthesis of nitrogen heterocycles	eng
dc.type	disertační práce	cze
dspace.entity.type	Publication