Sensitive approach for voltammetric determination of anti-inflammatory drug sulfasalazine using liquid mercury free silver solid amalgam electrode.

Abstract

Voltammetric study of the anti-inflammatory drug sulfasalazine was investigated employing polished silver solid amalgam electrode. One reduction and appropriate oxidation peak were recorded in a wide range of pH. The reduction peak was well developed and easily evaluable, and thus, it was chosen for further examination. The highest reduction response was observed in citrate buffer of pH 5 about the potential Ep = -0.1 V vs. Ag|AgCl. Parameters of adsorptive stripping square wave voltammetry were optimized, and it was reached excellent repeatability of measurements (RSD = 2.79 %) and determinations (RSD 5.33 %) as well, low limit of detection (LOD = 2.5 9 10-9 mol dm-3) and quantification (LOQ = 8.3 9 10-9 mol dm-3). Developed method was applied to the analysis of pharmaceutical preparation with excellent recovery (96.99–102.52 %). The designed method provides ‘‘environmental friendly’’ tool for sulfasalazine analysis and brings simple and sensitive tool for its determination.