Cyclodextrin-based potentiometric sensors for Metformin

Abstract

-Cyclodextrins ( -CDs) based polyvinylchloride (PVC) electrodes were fabricated and applied for potentiometric determination of Metformin (Mf). Matrix composition optimization was done referring the effect of type and content of -CDs, anionic sites and plasticizer. Electrodes incorporated with 2-hydroxypropyl- -CD as sensing ionophore, sodium tetrakis (4-florophenyl) borate (NaTFPB) as anionic site and o-nitrophenyloctyl ether (o-NPOE) as electrode plasticizer showed the best electroanalytical performances. The fabricated electrodes worked satisfactorily in the concentration range from 10-6 to 10-2 mol L-1 with detection limit reaching 7×10-6 mol L-1 and fast response time of 8 s. The developed sensors possessed improved selectivity and have been successfully applied for the potentiometric determination of Mf in pharmaceutical formulation. Comparison of the obtained results with those provided by reference method revealed adequate accuracy for control assay.