Electrochemical sensing in elimination voltammetry

Abstract

Elimination voltammetry with linear scan (EVLS) represents the fast and simple improvement of linear-sweep or cyclic voltammetric results. Through the various elimination functions, EVLS offers a new tool not also for better understanding of complex electrochemical processes on the surface of working electrodes, but also for improving the sensitivity of electrochemical measurements. The paper is mainly focused on the elimination function 'E4', which eliminates the kinetic and charging current components and conserves the diffusion one from a total current measured. It was found that this function has the most sensitive and separation ability in the case of adsorptive electroactive species. The strength of combination of EVLS with an adsorptive stripping technique was demonstrated by the enhancement and resolution of overlapped reduction signals of adenine and cytosine residues in short synthetic oligonucleotides (ODN) and DNA at the hanging mercury drop electrode. Two EVLS modes  single and double  are presented and their detection capabilities in analytical systems discussed.