Electrochemical oxidation of anti-inflammatory drug meloxicam and its determination using boron doped diamond electrode

Abstract

Voltammetric behavior of a nonsteroidal anti-inflammatory drug meloxicam was firstly studied using boron doped diamond electrode (BDDE). Two irreversible anodic current peaks were observed in wide pH range at potentials +900 mV and +1400 mV vs. saturated silver-silver chloride electrode. Mechanism of the electrochemical oxidation was proposed and confirmed using high performance liquid chromatography/mass spectrometry analysis of electrolyzed meloxicam solutions. Subsequently, an analytical method for meloxicam determination was developed using differential pulse voltammetry in connection with BDDE. This method provides low limit of detection (5.9 x 10(-8) mol L-1) and wide linear dynamic range (2.5 x 10(-7)-8.5 x 10(-5) mol L-1). Finally, model solutions as well as pharmaceutical preparations were successfully analyzed, and the meloxicam content was determined.