Synthesis and characterisation of chosen trifluoromethyl substituted salicylamides

Abstract

This bachelor's thesis is focused on the preparation of the series of compounds that are based on diamides derived from 5-chlorosalicylamide with different amino acid and 4-aminobenzotrifluoride. In total were prepared five original compounds of diamides. Intermediates have -benyzl (or rather O-Bn) protecting group to prevent unwanted reaction leading to unwanted substances. After reduction using hydrogen with catalyst palladium on carbon (Pd-C) the benzyl protecting group is released to receive hydroxyl group and the final products are obtained.