Electrochemical determination of anaesthetic drug benoxinate hydrochloride

Abstract

The electrochemical oxidation of Benoxinate hydrochloride (Ben) has been studied in Britton-Robinson buffer at electrochemically pretreated glassy carbon electrode (EA-GCE). Ben exhibits a well-defined irreversible oxidation peak over the entire range of pH 2-11. Differential pulse voltammetry (DPV) was used to determine the compound of interest in pure form, when the peak current varied linearly over the range of 4.0 × 10-7 – 3.2 × 10-6 mol L-1; the limits of detection and quantification being 8.3 × 10-8 mol L-1 and 2.8 × 10-7 mol L-1, respectively. The recovery was found in the range of 99.3-100.7%, the relative standard deviation in the range of ±0.75- 1.25%. The respective method proposed could be applied to determine Ben in pharmaceutical form.