Voltammetric determination of Azelastine-HCl and Emedastine dirumarate in micellar solution at glassy carbon and carbon paste electrodes

Abstract

The electrochemical behavior of the two antihistaminic drugs Azelastine-HCl and Emedastine difumarate is studied in micellar solutions. Anodic oxidation is obtained at the glassy carbon electrode (GCE) and a carbon paste electrode (CPE) using cyclic voltammetry(CV) and differential pulse voltammetry (DPV) in Britton-Robinson buffers (pH 8 and pH 6) containing 0.8×10-4 M sodium dodecylsulphate (SDS). The peak potential shifts to more positive value in anionic surfactant (sodium dodecylsulphate solution) than in presence of cationic surfactant (cetyltrimethylammonium bromide) or the non-ionic surfactant (Triton X-100). The oxidation was characterized by the single one-electron wave. The method has been validated according to the ICH Guidelines, when the limit of quantitation ranges between 0.4×10-7 and 0.8×10-7 mol L-1.