Modeling and prediction of the gradient retention data for ultrahigh performance liquid chromatography of benzodiazepines

dc.contributor.author	Valigurová, Petra
dc.contributor.author	Váňová, Jana
dc.contributor.author	Česla, Petr
dc.contributor.editor	Adam, Martin
dc.date.accessioned	2021-09-22T12:12:41Z
dc.date.available	2021-09-22T12:12:41Z
dc.date.issued	2021
dc.identifier.isbn	978-80-7560-387-6
dc.identifier.issn	1211-5541
dc.identifier.uri	https://hdl.handle.net/10195/78455
dc.description.abstract	This paper presents a method for prediction of the gradient retention times of six samples of benzodiazepines – phenazepam, pyrazolam, flubromazepam, meclonazepam, diclazepam, and diazepam. Isocratic and gradient separation of the compounds of interest was achieved on a Luna Omega C18 column followed by RP-LC/MS detection. The results have shown good agreement between the predicted and experimental retention data; however, higher differences were obtained for fast gradients in the ultrahigh performance separation mode.	en
dc.format	p. 61-71
dc.language.iso	en
dc.publisher	University of Pardubice	en
dc.relation.ispartof	Scientific papers of the University of Pardubice. Series A, Faculty of Chemical Technology. 27/2021	en
dc.rights	open access	en
dc.subject	benzodiazepines	en
dc.subject	liquid chromatography	en
dc.subject	gradient elution	en
dc.subject	prediction of retention	en
dc.title	Modeling and prediction of the gradient retention data for ultrahigh performance liquid chromatography of benzodiazepines	en
dc.type	Article	en
dc.peerreviewed	yes	en
dc.publicationstatus	published	en
dc.identifier.obd	39886612