Inhibitory effect of carbamates in two types of cholinesterases

Show simple item record Štěpánková, Šárka Vorčáková, Katarína 2020-06-10T08:23:03Z 2020-06-10T08:23:03Z 2013
dc.identifier.isbn 978-80-7395-748-3
dc.identifier.issn 1211-5541
dc.description.abstract Inhibitory effect of substituted 3-(diethylaminophenyl) phenyl carbamates in two types of cholineserases (acetylcholinesterase and butyrylcholinesterase) was determined. Inhibiting effectiveness was described by the value of IC50 (50 % inhibitory concentration). Modified spectrophotometric Ellman's method was used. Two types of choline esters were used as substrates for cholinesterases. It was proved that the carbamates chosen are quite effective inhibitors of cholinesterases. The most effective inhibitor of acetylcholinesterase is 3-(diethylaminophenyl) phenyl carbamate with the value of IC50 = 1.52 μM and the most effective inhibitor of butyrylcholinesterase is 3-(diethylaminophenyl) (3- nitrophenyl) carbamate with the value of IC50 = 1.70 μM. en
dc.format p. 49–56
dc.language.iso en
dc.publisher University of Pardubice en
dc.relation.ispartof Scientific papers of the University of Pardubice. Series A, Faculty of Chemical Technology. 19/2013 en
dc.rights open access en
dc.title Inhibitory effect of carbamates in two types of cholinesterases en
dc.type Article en
dc.peerreviewed yes en
dc.publicationstatus published en

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