Inhibitory effect of carbamates in two types of cholinesterases

dc.contributor.author	Štěpánková, Šárka
dc.contributor.author	Vorčáková, Katarína
dc.date.accessioned	2020-06-10T08:23:03Z
dc.date.available	2020-06-10T08:23:03Z
dc.date.issued	2013
dc.identifier.isbn	978-80-7395-748-3
dc.identifier.issn	1211-5541
dc.identifier.uri	https://hdl.handle.net/10195/75463
dc.description.abstract	Inhibitory effect of substituted 3-(diethylaminophenyl) phenyl carbamates in two types of cholineserases (acetylcholinesterase and butyrylcholinesterase) was determined. Inhibiting effectiveness was described by the value of IC50 (50 % inhibitory concentration). Modified spectrophotometric Ellman's method was used. Two types of choline esters were used as substrates for cholinesterases. It was proved that the carbamates chosen are quite effective inhibitors of cholinesterases. The most effective inhibitor of acetylcholinesterase is 3-(diethylaminophenyl) phenyl carbamate with the value of IC50 = 1.52 μM and the most effective inhibitor of butyrylcholinesterase is 3-(diethylaminophenyl) (3- nitrophenyl) carbamate with the value of IC50 = 1.70 μM.	en
dc.format	p. 49–56
dc.language.iso	en
dc.publisher	University of Pardubice	en
dc.relation.ispartof	Scientific papers of the University of Pardubice. Series A, Faculty of Chemical Technology. 19/2013	en
dc.rights	open access	en
dc.title	Inhibitory effect of carbamates in two types of cholinesterases	en
dc.type	Article	en
dc.peerreviewed	yes	en
dc.publicationstatus	published	en