Sensitive voltammetric method for determination of chemotherapeutic drug methotrexate using liquid mercury free silver solid amalgam electrode

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dc.contributor.author Bandžuchová, Lenka
dc.contributor.author Šelešovská, Renáta
dc.contributor.author Chýlková, Jaromíra
dc.date.accessioned 2020-05-20T08:24:48Z
dc.date.available 2020-05-20T08:24:48Z
dc.date.issued 2014
dc.identifier.isbn 978-80-7395-814-5
dc.identifier.issn 1211-5541
dc.identifier.uri https://hdl.handle.net/10195/75428
dc.description.abstract Voltammetric behaviour of a wide-spread used chemotherapeutic drug methotrexate (MTX) was investigated on a polished silver solid amalgam electrode (p-AgSAE) employing various voltammetric methods like cyclic voltammetry, direct current voltammetry and differential pulse voltammetry. It was found that MTX provided two reduction and one oxidation peak in an acidic medium, and the positively situated reduction signal (Ep = –340 mV), due its favorable analytical properties, was studied more in detail. 0.05 mol l–1 acetate buffer of pH 5 was selected as an optimum medium for monitoring of the MTX reduction on p-AgSAE. Operating parameters of differential pulse voltammetry were optimized and proposed voltammetric method provided high repeatability (relative standard deviation of 11 repeated measurements at concentration level of methotrexate of 1×10–7 mol l–1 equaled to 1.7 %), linear concentration range from 5×10–10 to 3×10–6 mol l–1 and low limit of detection (LD = 1.5×10–10 mol l–1). The applicability of proposed method was verified by analysis of real sample of chemotherapeutic preparation. en
dc.format p. 131–146
dc.language.iso en
dc.publisher University of Pardubice en
dc.relation.ispartof Scientific papers of the University of Pardubice. Series A, Faculty of Chemical Technology. 20/2014 en
dc.rights open access en
dc.title Sensitive voltammetric method for determination of chemotherapeutic drug methotrexate using liquid mercury free silver solid amalgam electrode en
dc.type Article en
dc.peerreviewed yes en
dc.publicationstatus published en


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