Zobrazit minimální záznam
dc.contributor.author |
Pařík, Patrik |
|
dc.contributor.author |
Šenauerová, Sylva |
|
dc.contributor.author |
Lišková, Vlasta |
|
dc.contributor.author |
Handlíř, Karel |
|
dc.contributor.author |
Ludwig, Miroslav |
|
dc.date.accessioned |
2010-10-26T09:47:22Z |
|
dc.date.available |
2010-10-26T09:47:22Z |
|
dc.date.issued |
2006 |
|
dc.identifier.issn |
0022-152X |
|
dc.identifier.uri |
http://hdl.handle.net/10195/37732 |
|
dc.description.abstract |
The reaction of methyl salicylate with ethane-1,2-diamine has been used to prepare 2-(2-hydroxyphenyl)-1H-imidazoline. This compound was alkylated with alkyl halides to give five new 2-(2-alkoxyphenyl)-1H-imidazolines (alkyl = propyl, isopropyl, isobutyl, sec-butyl, benzyl). Seven types of transformation reactions of imidazolines into the respective imidazoles were tested. Out of them successful were the dehydrogenation on palladium in toluene (several-day refluxing), oxidation with activated manganese dioxide in toluene
(several-hour heating at 60 °C), and the oxidation with potassium nitrosodisulfonate (Fremy’s salt) at room temperature. Seven new 2-(2-alkoxyphenyl)-1H-imidazoles were synthesized (alkyl = ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, benzyl) via mentioned methods. Comparison of individual oxidative aromatization reactions is discussed from the point of view of experimental arrangement, reaction time and conditions, purity of the products obtained, and yields. |
eng |
dc.format |
p. 835-841 |
eng |
dc.language.iso |
eng |
|
dc.publisher |
Wiley-Blackwell |
cze |
dc.relation.ispartof |
Journal of Heterocyclic Chemistry. 2006, vol. 43,
issue 4 |
eng |
dc.rights |
open access |
eng |
dc.subject |
Imidazolines |
eng |
dc.subject |
Imidazoles |
eng |
dc.subject |
Oxidation |
eng |
dc.subject |
Dehydrogenation |
eng |
dc.subject |
Palladium |
eng |
dc.subject |
Manganese Dioxide |
eng |
dc.subject |
Potassium Nitrosodisulfonate |
eng |
dc.title |
Study of synthesis of 2-(2-alkoxyphenyl)-1H-imidazoles. Comparison of oxidative aromatization reactions of imidazolines |
eng |
dc.type |
Article |
eng |
dc.peerreviewed |
yes |
eng |
dc.publicationstatus |
preprint |
eng |
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