New targeting system for antimycotic drugs: beta-Glucosidase sensitive Amphotericin B-star poly(ethylene glycol) conjugate

Drabina, Pavel; Sedlák, Miloš; Bílková, Eliška; Šimůnek, Petr; Buchta, Vladimír

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dc.contributor.author	Drabina, Pavel
dc.contributor.author	Sedlák, Miloš
dc.contributor.author	Bílková, Eliška
dc.contributor.author	Šimůnek, Petr
dc.contributor.author	Buchta, Vladimír
dc.date.accessioned	2010-10-01T12:14:07Z
dc.date.available	2010-10-01T12:14:07Z
dc.date.issued	2008
dc.identifier.issn	0960-894X
dc.identifier.uri	http://hdl.handle.net/10195/37279
dc.description.abstract	A new targeting potentially intravenous conjugate Amphotericin B (AMB)-star poly(ethylene glycol) (sPEG) (M = 25,160) has been synthesized and characterized. It contains a beta-D-glucopyranoside molecular switch which is sensitive to beta-glucosidases (E. C. 3.2.1.21). The beta-glucosidase-catalyzed release of AMB from the polymeric carrier was proved in vitro by means of spectrophotometry and HPLC. (C) 2008 Elsevier Ltd. All rights reserved.	cze
dc.format	p. 2952-2956	eng
dc.language.iso	eng
dc.publisher	Elsevier	cze
dc.relation.ispartof	Bioorganic and Medicinal Chemistry Letters. 2008, vol. 18, issue 9	eng
dc.rights	open access	eng
dc.title	New targeting system for antimycotic drugs: beta-Glucosidase sensitive Amphotericin B-star poly(ethylene glycol) conjugate	eng
dc.type	Article	eng
dc.peerreviewed	yes	eng
dc.publicationstatus	postprint	eng
dc.identifier.doi	10.1016/j.bmcl.2008.03.065
dc.relation.publisherversion	http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF9-4S50K3Y-1&_user=640852&_coverDate=05%2F01%2F2008&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000032310&_version=1&_urlVersion=0&_userid=640852&md5=5589e509fb97346fc3fd02e8e7a893e2&searchtype=a