New targeting system for antimycotic drugs: beta-Glucosidase sensitive Amphotericin B-star poly(ethylene glycol) conjugate

Drabina, Pavel; Sedlák, Miloš; Bílková, Eliška; Šimůnek, Petr; Buchta, Vladimír

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New targeting system for antimycotic drugs: beta-Glucosidase sensitive Amphotericin B-star poly(ethylene glycol) conjugate

Drabina, Pavel; Sedlák, Miloš; Bílková, Eliška; Šimůnek, Petr; Buchta, Vladimír

10.1016/j.bmcl.2008.03.065

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URI: http://hdl.handle.net/10195/37279

Datum publikování: 2008

Document type: Article

xmlui.ArtifactBrowser.SimpleSearch.filter.source: Bioorganic and Medicinal Chemistry Letters. 2008, vol. 18, issue 9

ISSN: 0960-894X

Publisher version: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF9-4S50K3Y-1&_user=640852&_coverDate=05%2F01%2F2008&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000032310&_version=1&_urlVersion=0&_userid=640852&md5=5589e509fb97346fc3fd02e8e7a893e2&searchtype=a

Abstract:

A new targeting potentially intravenous conjugate Amphotericin B (AMB)-star poly(ethylene glycol) (sPEG) (M = 25,160) has been synthesized and characterized. It contains a beta-D-glucopyranoside molecular switch which is sensitive to beta-glucosidases (E. C. 3.2.1.21). The beta-glucosidase-catalyzed release of AMB from the polymeric carrier was proved in vitro by means of spectrophotometry and HPLC. (C) 2008 Elsevier Ltd. All rights reserved.

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