Novel screen-printed sensors with chemically deposited boron-doped diamond and their use for voltammetric determination of attention deficit hyperactivity disorder medication atomoxetine
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Novel screen-printed sensors with chemically deposited boron-doped diamond and their use for voltammetric determination of attention deficit hyperactivity disorder medication atomoxetine
A novel lab-made disposable screen-printed sensor with chemically deposited boron-doped diamond (LM-SP/BDDE) was characterized by scanning electron microscopy (SEM), Raman spectroscopy, and compared to bulk boron-doped diamond electrode (BDDE) and commercially available screen-printed sensor with BDD working electrode (SP/BDDE). The sensors were applied for the determination of atomoxetine (ATX), a pharmaceutically active ingredient used to treat symptoms of attention deficit hyperactivity disorder (ADHD). Using bulk BDDE and a newly developed differential pulse voltammetric (DPV) method with optimized pre-treatment, DPV parameters, and in Britton-Robinson buffer of pH 2, obtained limit of detection ( LOD ) was 3.7 ×10 −8 mol L −1 . Subsequently, this new method was successfully transferred to the tested SP/BDDE sensors and verified on analysis of an ATX-containing drug Strattera 60MG with excellent repeatability (relative standard deviation ( RSD ) < 2.5% ( n = 5)). Moreover, elimination voltammetry with linear scan (EVLS) uncovered multiple (3-5) diffusion-controlled irreversible oxidation steps at all tested sensors.