dc.contributor.author |
Mužíková, Jitka
|
cze |
dc.contributor.author |
Holubová, Kateřina
|
cze |
dc.contributor.author |
Komersová, Alena
|
cze |
dc.contributor.author |
Lochař, Václav
|
cze |
dc.date.accessioned |
2017-05-11T11:20:23Z |
|
dc.date.available |
2017-05-11T11:20:23Z |
|
dc.date.issued |
2016 |
eng |
dc.identifier.issn |
0001-6837 |
eng |
dc.identifier.uri |
http://hdl.handle.net/10195/67713 |
|
dc.description.abstract |
Studies are described on the compressibility of directly compressible tableting materials containing two viscosity types of hypromellose in two concentrations and tableting materials containing additional glyceryl dibehenate, also in two concentrations. Compressibility is evaluated by means of the energy profile of the compression process and determination of tensile strength of tablets. Dissolution test examines the rate of release of the active ingredient from matrix tablets, which is subsequently evaluated mathematically. Increased concentrations of both hypromelloses and an addition of glyceryl dibehenate into tablets with both types of hypromellose improved compressibility. The rate of drug release was decreased with increasing viscosity degree of hypromellose and its increasing concentration. An addition of glyceryl dibehenate exerted the same influence on release as increased concentrations of the pertinent hypromellose. |
eng |
dc.format |
p. 461-468 |
eng |
dc.language.iso |
eng |
eng |
dc.relation.ispartof |
Acta Poloniae Pharmaceutica, volume 73, issue: 2 |
eng |
dc.rights |
open access |
eng |
dc.subject |
Dual matrix tablets |
eng |
dc.subject |
Energy profile of compression |
eng |
dc.subject |
Glyceryl dibehenate |
eng |
dc.subject |
Hypromellose |
eng |
dc.subject |
Release kinetics |
eng |
dc.subject |
Tensile strength of tablets |
eng |
dc.subject |
duální tablety |
cze |
dc.subject |
energetický profil lisování |
cze |
dc.subject |
glyceryl dibehenát |
cze |
dc.subject |
hypromelóza |
cze |
dc.subject |
rozpouštěcí kinetika |
cze |
dc.subject |
tenzní síla tablet |
cze |
dc.title |
Study of dual matrix tablets containing hypromellose of different viscosity degree and glyceryl dibehenate |
eng |
dc.title.alternative |
Studie duálních tablet obsahujících hypromelózu různého viskozitního stupně a glyceryl dibehenát |
cze |
dc.type |
article |
eng |
dc.description.abstract-translated |
Studie se zabývá lisovatelností přímo lisovaných tablet obsahujících hypromelózu a glyceryl dibehenát. |
cze |
dc.peerreviewed |
yes |
eng |
dc.publicationstatus |
published version |
eng |
dc.relation.publisherversion |
http://www.ptfarm.pl/download/7,2,43,20,37,27 |
|
dc.identifier.scopus |
2-s2.0-84975142381 |
|
dc.identifier.scopus |
2-s2.0-84975142381 |
|
dc.identifier.obd |
39878197 |
eng |