Digitální knihovnaUPCE
 

Pulmonary Arterial Hypertension in a Patient with Multiple Sclerosis Treated with Interferon Beta: A Case Report

ČlánekStatus neznámýpeer-reviewedpublished version
Náhled

Datum publikování

2016

Vedoucí práce

Oponent

Název časopisu

Název svazku

Vydavatel

Abstrakt

Pulmonary arterial hypertension (PAH) is characterized by elevation of mean pulmonary artery pressure to values conceivably approaching those seen in the systemic vascular bed. This occurrence is associated with a poor prognosis. PAH may result from a variety of causes, some of which are related to pharmacotherapy. Herein, we present a case of a 39-year-old female patient with relapsing-remitting multiple sclerosis (MS), who was receiving immunomodulatory therapy and subsequently developed severe PAH. We presume a causal relationship between the condition and the patient’s interferon beta therapy, which had spanned 10 years. The interferon beta therapy was stopped because its continued administration could have led to more rapid progression of severe pulmonary hypertension. Due to the severity of pulmonary arterial hypertension, PAH-specific pharmacotherapy was indicated, using sildenafil. Since 1998, only several cases of pulmonary arterial hypertension in patients treated with interferon beta have been documented in the scientific literature. In some of these instances, including in two case studies involving patients with multiple sclerosis, it was concluded that there was a possible association with this therapy.

Rozsah stran

p. 72-74

ISSN

2171-6625

Trvalý odkaz na tento záznam

Projekt

Zdrojový dokument

Journal of Neurology and Neuroscience, volume 7, issue: 1

Vydavatelská verze

http://www.jneuro.com/neurology-neuroscience/pulmonary-arterial-hypertension-in-a-patient-with-multiple-sclerosis-treated-with-interferon-beta-a-case-report.php?aid=8681

Přístup k e-verzi

open access

Název akce

ISBN

Studijní obor

Studijní program

Signatura tištěné verze

Umístění tištěné verze

Přístup k tištěné verzi

Klíčová slova

Multiple sclerosis, Pulmonary arterial hypertension, Interferon beta sildenafil, roztroušená skleróza, plicní arteriální hypertenze, Interferon Beta sildenafil

Endorsement

Review

item.page.supplemented

item.page.referenced